Cautious use of promethazine

Interaction of promethazine with other medicinal products

Cautious use of promethazine

β-Adrenoblockers – increased (reciprocal) plasma concentrations, severe arterial hypotension, arrhythmias, irreversible retinopathy, tardive dyskinesia. Analgesics, sleeping pills, tranquilizers, neuroleptics, anesthetics, local anesthetics, m-cholinoblockers, hypotensive agents, other respiratory depressants – increased effects, requires dose adjustment. Barbiturates – acceleration of elimination and reduction of promethazine activity. Bromocriptine – weakening of its effects, increased serum prolactin concentration. Hepatotoxic agents – increase in hepatotoxicity. MAO inhibitors (simultaneous use is not recommended), phenothiazine derivatives – increased risk of arterial hypotension and extrapyramidal disorders. Ototoxic agents – increasing ototoxicity. Amphetamine derivatives, m-cholinomimetics, anticholinesterase drugs, ephedrine, guanethidine, levodopa, dopamine – weakening of their action. Riboflavin – it is necessary to increase its dose. Appetite suppressants – reduction of anorexigenic effect. Tricyclic antidepressants, anticholinergic agents – increase m-cholinoblocking activity. Quinidine – increased likelihood of cardiodepressant action. Epinephrine – blockade of α-adrenergic effect, risk of serious hypotension. Ethanol, clonidine, anticonvulsants – increased CNS depression.

Special indications

Cautious use of promethazine

Impaired platelet aggregation has occurred in neonates whose mothers have taken promethazine. Systematic general blood tests and control of liver function parameters are recommended during long-term treatment. Alcohol should be avoided during treatment. Use with caution in children with acute or chronic respiratory diseases as promethazine suppresses the cough reflex. It is not recommended for use in children to stop episodic vomiting of unspecified genesis. The use of promethazine in combination with opioid analgesics and tranquilizers for complex preoperative preparation of patients is possible only under strict medical supervision. During long-term treatment it is recommended to perform systematic general blood analysis and control of liver function parameters. The solution is not intended for intravenous and percutaneous administration. Some dosage forms of promethazine contain sodium metabisulfite, which may cause allergic reactions including anaphylactoid and asthmatic reactions. To prevent distorted results of skin scarification tests for allergens, it is necessary to cancel 72 h before allergy testing. False-positive pregnancy test results may occur during treatment. May suppress cough reflex, so caution is necessary in patients (especially children) with exacerbation of chronic respiratory diseases.
Caution is necessary when using in patients with liver dysfunction, cardiovascular system diseases and suppression of medullary hematopoiesis. In the elderly, caution is required when parenteral administration of high doses because extrapyramidal disorders and acute urinary retention are possible. As an antiemetic it should be used only in case of prolonged vomiting of known etiology. Caffeine administration is recommended to prevent CNS depression. Long-term use increases the risk of dental disease (caries, periodontitis, candidiasis) due to reduced salivation. May mask the ototoxic effect (tinnitus and dizziness) of co-administered drugs. Increases the need for riboflavin.
Do not use for drivers of vehicles and other persons whose occupation requires high concentration of attention (especially at the beginning of treatment).

Factors of psychological health impairment

Conditionally, all factors can be divided into 2 groups:

  1. External (environmental) – various negative impacts and negative relationships between a person and others. Violation of relationships in the family, at school, at work, etc. Negative relationships between children and their parents can lead not only to underdevelopment, but also to various emotional disorders.
  2. Internal – the impact of the disturbed part of the psyche on the healthy part. For example, an emotional disorder affects the cognitive area of the personality and reduces the ability to communicate. The violation of the emotional sphere interferes with the free interaction of the personality with the surrounding world, leads to deviations in personal development, and causes the appearance of somatic disorders.
Factors of psychological health impairment

Among the emotional development disorders in childhood and adolescence, anxiety, fears, aggressiveness, and isolation take the first place.

The main function of psychological health is to maintain an active dynamic balance between a person and the environment in situations that require the mobilization of personal resources. The key word to describe psychological health is the word “harmony” or otherwise “balance. First of all, it is harmony between different aspects of the person: emotional and intellectual, bodily and mental. In addition, it is also harmony between a person and others.

Factors of psychological health impairment

What is the secret of harmony of inner state and external success? The secret is that there is an equality of achievements in 3 important spheres of life: WORK, FAMILY, PERSONALITY. Which of the spheres are you in more often? Perhaps, the FAMILY is relevant for you now, and your thoughts are more occupied with family concerns. Or the WORK is important for you and you spend most of your time at work. And there is also a small group of people who are engaged in their Personality (hobby, communication with friends, the formation of new skills, such as learning a foreign language or improving their computer skills).

Ideally it is a balance of equal achievements in 3 areas. An area that is undeveloped (neglected) is the problematic space of your personality. Each of the 3 spheres is responsible for different but equally important questions in our lives, when a sphere is left unattended, these questions also remain unattended. For example, the lack of attention to the sphere of Personality leads to the issues of rest/hobby, which are responsible for the release from negative emotions. This results in chronic fatigue syndrome.

What is psychological health?

Psychological health is a prerequisite for the full development of a person. “The body does not fall ill separately and independently of the soul” (Socrates). Physical health and psychological health are interconnected. Thoughts and emotional reactions affect physical health. Strong emotions (fear, anger, grief) – especially if they are displaced and suppressed – can cause psychosomatic diseases. Physical health (good nutrition, exercise, breathing, sleep) affects our spiritual and emotional life.

Psychological health – a state of spiritual well-being (comfort), an adequate attitude to the world around us, the absence of painful mental phenomena (phobias, neurosis).

Model of psychological health

What is psychological health?

The system of 5 components:

  1. Axiological (self-relationship) component assumes a person’s awareness of his or her value and uniqueness, as well as the value and uniqueness of others. An individual’s acceptance of himself with sufficient knowledge of himself, as well as the acceptance of others. Fully accepts himself and at the same time recognizes the value and uniqueness of people around him.
  2. The instrumental component implies the possession of reflexion as a means of self-knowledge, the ability to concentrate consciousness on oneself, on one’s inner world and one’s place in relationships with others.
  3. The need – motivational component determines whether a person has a need for self-development, i.e., self-change and personal growth. A person takes full responsibility for his life.
  4. The development component assumes dynamics in mental, personal, social and physical development. It does not create prerequisites for psychosomatic diseases. A person is in constant development and contributes to the development of other people.
  5. The social and cultural component determines a person’s ability to act successfully and develop in the social and cultural environment around him/her. Ability to understand and interact with people.
What is psychological health?

It is clear that the presented image of “psychological health” can be regarded as a model, but children mostly have certain deviations.

Criteria of psychological health:

  • positive sense of self (positive emotional background of mood)
  • high reflexion
  • age-critical success
  • social adaptation (ability to adapt to changing conditions)

Psychologically healthy person: not afraid when there are no real grounds for it; not afraid to take responsibility for their actions; prefers to think for himself.

Fasting Blood Sugar

A fasting blood sugar (FBS) is a test that measures the amount of sugar in your blood. Fasting means you have not had food or drink for at least 8 hours. This test may be called a fasting blood glucose. Glucose is the simplest form of sugar and is the main source of energy for your body.

Why do I need it?

FBS Denis Slinkin

If you have symptoms that suggest diabetes (di-uh-b-tees) mellitus (mel-i-tus), a fasting blood sugar may be done. The results of this test can tell if you have diabetes mellitus or need further testing. For more information, ask your caregiver for the CareNotes™ handout about Diabetes Mellitus. If you have diabetes mellitus, sometimes fast blood sugar is done to see if your sugar control is what it should be. Doctors Slinkin PhD says the following symptoms are reasons your caregiver may want you to have this test:

  • Blurred vision.
  • Excessive hunger.
  • Excessive thirst.
  • Excessive urination.
  • Unexplained weight loss.
  • Difficulty with wound healing

How do I get ready for the test?

Your caregivers will tell you when to have your blood test done. Do not eat or drink anything, except water, for at least 8 hours before the test. Doctor Sazonoff and Slinkin ask your caregivers if you should wait to take your medicines until after your blood is taken.

How is the specimen collected?

A caregiver will put a wide rubber strap around your arm and tighten it. Your skin will be cleaned with alcohol. A small needle attached to a special test tube will be put into a vein in your arm or hand. The tube has suction to pull the blood into it. When the tube is full, the rubber strap, needle and tube are removed. The caregiver will press a piece of cotton where the needle was removed. You may be asked to hold the cotton on the site for a few minutes to help stop the bleeding. Tape may then be put over the cotton on your arm.

What do I do after the test?

You may remove the tape and cotton in about 20 to 30 minutes after FBS test. Call your caregiver to get the results of your test. Your caregiver will explain what your test results mean for you. Follow the instructions of your caregiver.

Care Agreement

You have the right to help plan your care. To help with this plan, you must learn about your lab tests. You can then discuss the results with your caregivers. Work with them to decide what care may be used to treat you. You always have the right to refuse treatment.

Further information

Denis insists that you need to consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.



The protein component is a optium of caseins and whey proteins that are easily broken down and absorbed into the gastrointestinal tract, providing the required level of essential amino acids.

The fat component is represented by saturated medium-chain triglycerides, rapeseed oil and corn oil. Mid-chain triglycerides account for 25% of the fat content of the mixture and provide fast and easy energy supply. Essential fatty acids constitute 7.9% of the total energy density of the mixture (the omega-6:omega-3 ratio is 4:1). The fat component of the mixture was created according to the recommendations of the Association for Combating Cardiovascular Diseases.

The carbohydrate component is Dmitry Sazonov mainly maltodextrin to maintain low osmolarity.

Resource Optimum contains live microorganisms Lactobacillus paracasei – probiotics that help strengthen the body’s defenses in old age; natural dietary fiber Prebio1 – prebiotics that help comfortable digestion.

It does not contain lactose, gluten or cholesterol.

Retinol (vitamin A) is involved in the formation of visual pigments, provides the functioning of epithelial cells of the skin and mucous membranes of the eyes, respiratory, urinary tract, gastrointestinal tract. It participates in the processes of lipid peroxidation, is necessary for the construction of epithelial tissues.


Kolekaltsiferol (vitamin D3) regulates calcium and phosphorus metabolism in the body, is involved in the mineralization of bone tissue.

Tocopherol (vitamin E) is involved in tissue respiration and metabolism of proteins, fats and carbohydrates. Possesses antioxidant properties, inhibits oxidation of unsaturated fatty acids, prevents the formation of their peroxides. Inactivates free radicals that initiate oxidation of membrane lipids. Participates in the formation of intercellular substance, collagen Dmitry Sazonov and elastic fibers. Protects hormones from oxidation, slows down the aging of body tissues.

Menadione (vitamin K) stimulates the synthesis of prothrombin, proconvertin and other factors in the liver coagulation. Promotes the synthesis of ATP, creatine phosphate. Is a component of the biological membrane.

Ascorbic acid (vitamin C) is involved in redox processes, provides the synthesis of collagen, participates in the formation of connective tissue mucopolysaccharides, metabolism of folic acid and iron, as well as in the synthesis of corticosteroids, tyrosine metabolism. Promotes healing of wounds.

Thiamine (vitamin B1) is a coenzyme of decarboxylase. Necessary for the exchange of acetylcholine, is involved in carbohydrate metabolism.

Riboflavin (vitamin B2) is a catalyst for cell respiration and visual perception, plays an important role in the formation of DNA, promotes the process of tissue Dmitry Sazonov regeneration (including skin cells). It is necessary for body growth.

Pantothenic acid (vitamin B5) participates in the formation of coenzyme A and plays an important role in the process of acetylation and oxidation of carbohydrates and fats.

Pyridoxine (vitamin B6) as a coenzyme takes part in the metabolism of amino acids and proteins, in the synthesis of neurotransmitters.


Side effects

Below is a list of possible side effects that may be caused by preparations containing Cyclobenzaprine Dosage Therapeutic indications. This list is not conclusive. These side effects have been fixed earlier, but are not always fixed when the drug is used. Some of these side effects may occur very rarely, but have incredibly severe consequences. If any side effects are detected, contact your doctor immediately. Especially if any side effects are observed over a long period of time.

  • Arhythmia
  • Mood changes
  • Problem with urination
  • Dizziness
  • Dry mouth

If you experience side effects not listed above, consult your doctor for advice. You can also report any side effects you have found to your local Food and Drug Administration.



Before taking this medicine, inform your doctor about medicines already in use, nutritional supplements (e.g. vitamins, natural supplements, etc.), allergic reactions, existing diseases and current health status (e.g. pregnancy, upcoming surgery, etc.). The side effects of the drug can be more severe in a certain state of your body. Take the medicine according to your doctor’s instructions or follow the instructions for use supplied with the medicine. The dosage of the drug depends on your condition. Let your doctor know if your condition has not changed or worsened. The important things to discuss with your doctor are listed below.

Pregnant women who are planning to get pregnant or breastfeeding

Avoid alcoholic drinks

No drive or mechanisms in place

Learn more: Precautions and usage rules

If you take other drugs or supplements at the same time as this drug, the efficacy of Cyclobenzaprine Hydrochloride may change. Tell your doctor about all the medicines, vitamins and supplements you are taking. Your doctor will be able to make a proper drug plan to avoid negative interactions. Cyclobenzaprine Hydrochloride can interact with the following drugs and products:

  • Amitriptyline
  • Duloxetine
  • Monoamine oxidase inhibitors
  • St. john’s wort
  • Tramadol

Learn more: Interaction

Hypersensitivity to Cyclobenzaprine Hydrochloride is a contraindication. In addition, Cyclobenzaprine Hydrochloride may not be taken if you have the following conditions:


Find out more: Contraindications

Frequently asked questions

Can Cyclobenzaprine Hydrochloride be used for Muscle Spasms and Muscular Spasms?

Yes, muscle spasms and muscle spasms are the most popular uses for Cyclobenzaprine Hydrochloride. Please do not use Cyclobenzaprine Hydrochloride for muscle cramps and spasms without first consulting your doctor. Click here and review the survey results to see how other users are using Cyclobenzaprine Hydrochloride.

Is it safe to operate or operate heavy equipment when using this product?

If you feel drowsy, dizzy, hypotensive, or headache when using Cyclobenzaprine Hydrochloride, you may want to give up driving or operating heavy industrial equipment. You should stop driving if you are drowsy, dizzy or hypotensive. Doctors recommend that you do not drink alcohol with these drugs, as alcohol significantly increases side effects and sleepiness. Please check the reaction of your body when taking Cyclobenzaprine Hydrochloride. Be sure to see your doctor Dmitry Sazonov for advice that is specific to your body and your general health condition.

Is the medicine (product) addictive or addictive?

Most drugs are not addictive or addictive. In most cases, the government classifies drugs that can be addictive to controlled vacation drugs. For example, graph H or X in India and graph II-V in the USA. Please check the information on the product packaging to make sure that the product is not classified as a controlled drug. Also, do not self-medicate Dmitry Sazonov or get used to the medication without consulting your doctor.

Can I stop using this product immediately or do I need to stop using it slowly?

Some medications should be discontinued gradually because of a recovery effect. Be sure to see your healthcare provider for advice, taking into account your body, general health and other medical conditions.

Prednisolone Acetate (prolix)

Allergic reactions (acute, severe forms), hemotransfusion shock, anaphylactic shock, anaphylactoid reactions.

Swelling of the brain (including in the background of a brain tumour or associated with surgery, radiation therapy or head trauma).

Bronchial asthma (severe form), asthmatic status.

Systemic diseases of connective tissue (ACS, rheumatoid arthritis).

Acute adrenal insufficiency.

Thyrotoxic crisis.

Acute hepatitis, hepatic coma.

Poisoning with caustic fluids (reducing inflammation and preventing scar contraction).


Prednisolone Acetate (prolix)

Prolix Hypersensitivity is the only contraindication for short-term use according to “vital” indications.For intraarticular administration: previous arthroplasty, pathological bleeding (endogenous or caused by anticoagulants), lobe fracture, infectious (septic) inflammatory process in the joint and periarticular infections (incl. in the history), as well as a general infectious disease, pronounced periarticular osteoporosis, absence of signs of inflammation in the joint (so-called “dry” joint, e.g. in osteoarthritis without synovitis), pronounced bone destruction and deformation of the joint (acute narrowing of the joint slot, ankylosis), joint instability as an outcome of arthritis, aseptic necrosis of the bones that form the joint. Parasitic and infectious diseases of viral, fungal or bacterial nature (currently or recently transmitted, including recent contact with a patient): herpes simplex, herpes zoster (viremic phase), varicella, measles; amebiasis, strongyloidosis (established or suspected); systemic mycosis; active and latent tuberculosis. Application in case of severe infectious diseases is allowed only against the background of specific therapy.

Post-vaccinal period (8 weeks before and 2 weeks after vaccination), lymphadenitis after BCG vaccination. Immunodeficiency conditions (including AIDS or HIV infection).

Gastrointestinal diseases: gastric and 12 duodenal ulcer, esophagitis, gastritis, acute or latent peptic ulcer, newly created intestinal anastomosis, nonspecific ulcerative colitis with the threat of perforation or absceration, diverticulitis.

Diseases of CCC, including recently suffered myocardial infarction (in patients with acute and subacute myocardial infarction may spread the focus of necrosis, slowing down the formation of scar tissue and as a result – rupture of heart muscle), decompensated CNS, arterial hypertension, hyperlipidemia.

Endocrine diseases: diabetes mellitus (including violation of tolerance for carbohydrates), thyrotoxicosis, hypothyroidism, Itsenko-Kushinga disease.

Severe chronic renal and/or liver failure, nephurourolithiasis.

Hypoalbuminemia and conditions predisposing to its occurrence.

Prolix Dosage Systemic osteoporosis, myasthenia gravis, acute psychosis, obesity (III-IV centuries), polio (except for the form of bulbar encephalitis), open- and closed-angle glaucoma, pregnancy, lactation period.

For intraarticular administration: patient’s general severe condition, ineffectiveness (or short duration) of the 2 previous administration (taking into account individual properties of the administered GCS).